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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-613
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB cell lines SO-RB50, Y79 and WERI-RB1; RPE cell line ARPE-19; RB samples, normal retinas
Methods transfection, qPCR, MTT assay, colony formation assay, BrdU staining, transwell assay, flow cytometry, Western blot, xenograft
Expression pattern down-regulated
Functional description miR-613 functions as a tumor suppressor in retinoblastoma through downregulating E2F5, supporting the targeting of the novel miR-613/E2F5 axis as a potentially effective therapeutic approach for retinoblastoma.
PubMed ID 28351331
Year 2017
Title MiR-613 suppresses retinoblastoma cell proliferation, invasion, and tumor formation by targeting E2F5.
Drug-related ncRNA NO

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